Modulation of Bronchial Epithelial Barrier Integrity
... by Low Molecular Weight Components from Birch Pollen.
Recent publication
Birch pollen contains both allergens and low-molecular components. A project of the Danube Allergy Research Cluster investigated whether and how these low-molecular components of birch pollen influence the allergic immune response, specifically the epithelial barrier. The scientists used human epithelial cell layers and treated them in vitro with the main birch pollen allergen Bet v 1, an aqueous birch pollen solution and low-molecular components of birch pollen. The electrical resistance of the epithelial layer and the release of cytokines were measured 24 hours after treatment. This allowed a statement to be made about which components of birch pollen have what effect on the integrity of the epithelial membrane. The results of the study have been made freely accessible in the International Journal of Molecular Sciences thanks to open access funding from KL.
Sudharson, S, Kalic, T, Eckl-Dorna, J, Lengger, N, Breiteneder, H & Hafner, C 2024, 'Modulation of Bronchial Epithelial Barrier Integrity by Low Molecular Weight Components from Birch Pollen', International Journal of Molecular Sciences, vol. 25, no. 13, 7374. https://doi.org/10.3390/ijms25137374
Srinidhi Sudharson MSc
Scientific Staff (PreDoc), Scientific Staff (PreDoc)
Scientific Working Group Allergology and Immunology, Division of Dermatology and Venereology (University Hospital St. Pölten)
Tanja Kalic Kamath PhD
Scientific Staff (PostDoc), Scientific Staff (PostDoc)
Scientific Working Group Allergology and Immunology, Division of Dermatology and Venereology (University Hospital St. Pölten)
PD Dr. Christine Hafner
Division of Dermatology and Venereology (University Hospital St. Pölten)
