Deletion of the α2δ-1 calcium channel subunit increases excitability of mouse chromaffin cells
Recent publication
High voltage-gated calcium channels are significantly involved in the regulation of hormone release in endocrine cells. These calcium channels consist of various subunits that are encoded by several genes. If the apha2deta-1 subunit fails due to gene mutations, the influx of calcium into the cell is reduced. Researchers from Innsbruck, Turin and Krems were able to show in an in vivo test system that the excitability of the cell is increased despite the reduced calcium influx. This circumstance is unexpected on the one hand and leads to an increased release of catecholamines on the other. The results are consistent with and may explain cardiovascular manifestations in patients whose apha2deta-1 subunit is inactive.
Geisler, SM, Ottaviani, MM, Jacobo-Piqueras, N, Theiner, T, Mastrolia, V, Guarina, L, Ebner, K, Obermair, GJ, Carbone, E & Tuluc, P 2024, 'Deletion of the α2δ-1 calcium channel subunit increases excitability of mouse chromaffin cells', Journal of Physiology. https://doi.org/10.1113/JP285681
Univ.-Prof. Mag. Dr. Gerald Obermair
Head of
Division of Physiology
