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STAT3 | D. Stoiber-Sakaguchi
Tuesday, 16. July 2024

The protein STAT3 helps the immune system to recognise leukemic cells. This interaction, which is important for future immunotherapies, is now understood in detail thanks to a study at the Karl Landsteiner University of Health Sciences (KL Krems). The study showed that STAT3 influences the formation of surface structures on leukemic cells that make them vulnerable to the immune system. If these structures are missing, leukemic cells can escape the body's innate immune surveillance. The expression of STAT3 in and the surface structures on leukemic cells could be a potential biomarker for future immunotherapies.

Stefan Stieger

A career in research spanning technology and psychology

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A research group led by Thomas Eiwegger, MD, Head of the Clinical Department of Pediatrics and Adolescent Medicine at the University Hospital in St. Pölten and Assoc Prof of Karl Landsteiner University and the University of Toronto, is providing new insights into acute food allergies. The researchers published in the "European Journal of Allergy and Clinical Immunology" a new model based on human intestinal tissue samples.
Food allergies affect up to 10% of children in certain areas and are on the rise. Allergen exposure in food-allergic children can result in life-threatening reactions. Given the lack of treatment and markers of food allergy, new models to study mechanisms and new treatment options for food allergy are required.

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Choosing the appropriate timing for specialized palliative care can have a positive impact on life expectancy for patients with small cell lung cancer. This is the result of a recently internationally published study by the Karl Landsteiner University of Health Sciences (KL Krems, Austria). There, the relevant data of 152 patients were evaluated at the Krems University Hospital. The result shows a differentiated picture: the life expectancy of those affected depends both on the reason for referral for special palliative care and on its starting time relative to the course of the disease.

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A mobile augmented reality game fosters sense of belonging in adolescents. The D.O.T. (Die Offene Tür - The Open Door) research team of the Karl Landsteiner University of Health Sciences and the Ludwig Boltzmann Society designed the educational game.

Ingrid Metzler
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On 17.11.2022, the Lower Austrian Society for Research Promotion (GFF) awarded the Impact Award to PhD students for the first time. The award was given to science projects with the highest relevance for the scientific community as well as for the general public. All projects were funded by the province of Lower Austria within the framework of the Science Calls 2016 to 2019. In the poster presentations of the still ongoing research projects from the Science Calls 2018 and 2019, our Carmen Rehm reached 1st place with a visually and content-wise outstanding poster!

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Age tech refers to emerging and new technologies designed to assist older adults and to promote their health. Many applications are based on artificial intelligence or machine-based learning systems. Univ.-Prof. Dr. Giovanni Rubeis explains why equity must essentially be denoted during the design process of AgeTech. To avoid exclusion and disadvantage of individuals through the use of Age-Tech, regulations alone are not sufficient.

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A team from the Karl Landsteiner University in Krems, Austria, finds a high redundancy in proteins that modulate neuronal networks and neuronal signal transmission

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With the help of a self-constructed 3D model, senior physicians PD Dr Bela Büki and Dr Michael Bauer research together with colleagues from the Johns Hopkins University, Baltimore, USA the reasons for shadows in MR images of the inner ear and explain how the results can be useful in everyday clinical practice.

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The Division of Psychological Methodology at the Karl Landsteiner University of Health Sciences (KL) developed a method to efficiently measure perceptions in real time and in the natural environment of participants.

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A recent study investigated the influence intelligence and self-control can have on a successful life.

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