STAT3 in acute myeloid leukemia facilitates natural killer cell-mediated surveillance
Recent publication
Research into the role of STAT3, a component of the JAK-STAT signalling pathway, in the development of acute myeloid leukaemia is a focus of the Division of Pharmacology. Together with researchers from the Division of Physiology, the team led by Prof. Dr. Dagmar Stoiber-Sakaguchi has gained new insights into the body's own immune defence in the fight against cancer. Natural killer cells are responsible for recognising and eliminating cancer cells. STAT3 seems to play an important role in this recognition process. Cancer cells that are unable to produce STAT3 are poorly recognised and eliminated by natural killer cells because they release less ICAM-1, a molecule on the cell surface. The study suggests that the STAT3/ICAM-1 axis could be a potential biomarker for the treatment of acute myeloid leukaemia. The paper, published open access in the journal Frontiers in Immunology, was supported by various funding organisations including the Austrian Science Fund, the Province of Lower Austria (K3) and Gesellschaft für Forschungsförderung NÖ.
Witalisz-Siepracka, A, Denk, C-M, Zdársky, B, Hofmann, L, Edtmayer, S, Harm, T, Weiss, S, Heindl, K, Hessenberger, M, Summer, S, Dutta, S, Casanova, E, Obermair, GJ, Győrffy, B, Putz, EM, Sill, H & Stoiber, D 2024, 'STAT3 in acute myeloid leukemia facilitates natural killer cell-mediated surveillance', Frontiers in Immunology, vol. 15. https://doi.org/10.3389/fimmu.2024.1374068
Agnieszka Witalisz-Siepracka PhD
Scientific Staff (PostDoc)
Division of Pharmacology
Bernhard Zdársky PhD
Scientific Staff (PostDoc)
Division of Pharmacology
Sophie Rosa Edtmayer MSc
Scientific Staff (PreDoc)
Division of Pharmacology
Theresa Harm MSc
Scientific Staff (PreDoc)
Division of Pharmacology
Kerstin Heindl MSc
Biomedical analyst
Division of Pharmacology
Dr. Manuel Hessenberger MSc
Scientific Staff (Sen. PostDoc), Safety Officer
Division of Physiology
Univ.-Prof. Mag. Dr. Gerald Obermair
Head of
Division of Physiology
Univ.-Prof. PD MMag. Dr. Dagmar Stoiber-Sakaguchi
Head of
Division of Pharmacology
