blood cells

HepBinProt

Heparin binding antimicrobial proteins in human plasma

  • Project number: LSC20-021
  • Project management: Jens Hartmann, Danube University Krems / Center for Biomedical Technology
  • Project partners: Karl Landsteiner Private University for Health Sciences / Department of Water Quality and Health
  • Project duration: 36 months from 1 March 2022

Background

The aim of this project is to investigate endotoxin-neutralizing mechanisms in blood. One focus is the
influence of anticoagulation on the effect of endotoxins and on endotoxin-neutralizing factors in the blood.
In addition, so-called host defence peptides (HDPs) will be isolated from human whole blood and their influence on endotoxin activity will be investigated.
The activity of endotoxins will be investigated. Subsequently, the HDPs will be characterized with respect to their molar mass.
will be characterized.