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STAT3 | D. Stoiber-Sakaguchi
Tuesday, 16. July 2024

The protein STAT3 helps the immune system to recognise leukemic cells. This interaction, which is important for future immunotherapies, is now understood in detail thanks to a study at the Karl Landsteiner University of Health Sciences (KL Krems). The study showed that STAT3 influences the formation of surface structures on leukemic cells that make them vulnerable to the immune system. If these structures are missing, leukemic cells can escape the body's innate immune surveillance. The expression of STAT3 in and the surface structures on leukemic cells could be a potential biomarker for future immunotherapies.

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A novel compound against breast cancer improves the efficiancy of standard cancer treatment and shows superior tolerability in laboratory tests when compared to similar agents, setting the stage for its further clinical development. The mechanism of action of this compound is based upon the re-activation of naturally occurring “programmed” cell death or apoptosis, that is switched off by many cancer cells thereby leading to their uncontrolled proliferation. Results of this study have now been published by physician-scientists from the Karl Landsteiner University of Health Sciences, Krems together with colleagues from the University of Heidelberg, Harvard Medical School, St. Jude’s Children’s Research Hospital, the Huazhong University and others.

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On Wednesday, December 5, NÖGUS Chairman Martin Eichtinger and the Rector of the Karl Landsteiner Private University Rudolf Mallinger opened the first competence centre for gerontology and health research in Austria. Under the direction of the recognized sociologist and gerontologist Ao. Univ.-Prof. Dr. Franz Kolland, the centre at the Karl Landsteiner University in Krems will start immediately with a showcase project. The broad-based study "Lower Austrian Health Age Barometer" will develop scientific basics and concepts for the care of the population aged 60 and over by the end of 2019. The focus will be on health care, health care, nursing and the use of digital technologies.

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In Lower Austria, medical education and research are being further expanded. Today, Johanna Mikl-Leitner, governor, Stephan Pernkopf, deputy governor, Rudolf Mallinger, rector of the Karl Landsteiner University and Markus Klamminger, medical director of the Lower Austrian Clinic Holding, presented further steps. Six million euros for research and teaching at the university hospitals of Krems, St. Pölten and Tulln.

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Recently the Young Researchers' Calendar 2019 was presented in the Lower Austrian State Library. Once again, the models are young researchers working at the four ecoplus Technopol locations. "The research landscape at the Lower Austrian technopoles is a breeding ground for highly innovative, exciting research projects and the workplace of a modern, young generation of researchers! In our young researchers' calendar we present twelve people whose above-average achievements give Lower Austria's technology locations a head start - because we know: Research is the future", emphasised Petra Bohuslav, Regional Councillor for Economics and Technology, and Helmut Miernicki, Managing Director of ecoplus, at the presentation of the calendar.

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Researchers from Karl Landsteiner University of Health Sciences identify addiction-like behaviour after time away from social media. In many cases, just a seven-day break from social media platforms such as Facebook and WhatsApp is sufficient to induce withdrawal symptoms like those caused by addictive substances. This is the conclusion of a study by Austrian scientists, which was published today in an international journal. The study identified classic withdrawal symptoms, including significantly increased urges, boredom, and an influence on whether the subjects were in a good or bad mood. Most surprisingly, 90 of the 152 participants were unable to do without social media for seven days without “relapsing”.

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On the occasion of the 150th birthday of Karl Landsteiner and out of personal interest, Dr. Eleonore Kemetmüller, Head of the Department of Nursing Science at KL, travelled to the USA.

The answer will be explained by Univ.-Prof. DI Dr. Dieter Pahr, biomechanic at KL University in P.M.Wissen on ServusTV.

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At a planned meeting with Prof. Kari Martinsen and Prof. Herdis Alvsvag, Norway's most renowned nursing scientists, an intensive exchange of ideas took place on the current development of professional nursing.

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Being able to distinguish forced from hearty laughter is a human ability that is spread across cultural boundaries.

Glioblastoma is a brain cancer with devastating prognosis. A new collaborative study by scientists from CeMM, MedUni Vienna, KL University and the Austrian Brain Tumor Registry network demonstrates how epigenetic analysis of tumor samples collected in routine clinical practice could be used to better classify and treat the disease. The KL researchers Dr. Melitta Kitzwögerer, Dr. Franz Marhold and Prim. Dr. Stefan Oberndorfer (all from the University Hospital St. Pölten) were also involved in the research work. The results were published in Nature Medicine.

In order for organ models to be suitable as training objects for surgeons, their mechanical properties must also match the biological model as closely as possible.

Karl Landsteiner University of Health Sciences in Krems launches project to study the growth of water-based microorganisms

In order to better understand and assess the quality of ground and spring water, state-of-the-art methods from the fields of molecular biology and microbiology, as well as chemical high-performance analytics are now developed. This has been made possible by a project currently underway at the Karl Landsteiner University of Health Sciences (KL). The aim of the project is to combine new technologies across a number of disciplines to evaluate the growth of water-based bacteria and their biochemical processes. This will make it possible to determine and predict the biostability of water with much more accuracy than before, thus making a fundamental contribution to water hygiene and health. The project, which is funded by the federal state of Lower Austria, is based on internationally recognised research conducted at the Interuniversity Cooperation Center Water & Health (ICC Water & Health) and at the Department of Agrobiotechnology, IFA-Tulln, University of Natural Resources and Life Sciences Vienna, which enable bacteria and their activities in water samples to be precisely characterised.

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