Favorable impact of PD1/PD-L1 antagonists on bone remodeling
An exploratory prospective clinical study and ex vivo validation
Recent publication
Researchers from the KL conducted a longitudinal study in cancer patients to assess the effect of immune checkpoint inhibitors (ICIs) on bone health. ICIs are a common treatment option for cancer, but little is known about their effects on bone health. To support the results of the in vivo study that assessed the effect of ICIs, additional cell analyses were performed. Surprisingly, the researchers found that ICIs may even have a positive effect on bone health in cancer patients. The work was funded by the Lower Austria Research Promotion Agency and a seed grant, a funding measure of the KL's research impulse. It has been published in the Journal for ImmunoTherapy of Cancer thanks to open access funding from the KL.
Gassner, T, Chittilappilly, C, Pirich, T, Neuditschko, B, Hackner, K, Lind, J, Aksoy, O, Graichen, U, Klee, S, Herzog, F, Wiesner, C, Errhalt, P, Pecherstorfer, M, Podar, K & Vallet, S 2024, 'Favorable impact of PD1/PD-L1 antagonists on bone remodeling: an exploratory prospective clinical study and ex vivo validation', Journal for ImmunoTherapy of Cancer, vol. 12, no. 5, e008669. https://doi.org/10.1136/jitc-2023-008669
Tamara Gassner MSc
Medical-technical specialist
Institute of Laboratory Medicine (Central Laboratory) (University Hospital St. Pölten)
Dr. Theo Pirich BSc
Division of Neurology (University Hospital St. Pölten)
OA Clin. Ass. Prof. DDr. Klaus Hackner
Division of Pneumology (University Hospital Krems)
Dr. Osman Aksoy
Scientific Staff (PostDoc)
Division of Molecular Oncology and Hematology
Dr. Uwe Graichen
Scientific Staff (PostDoc)
Division of Biostatistics and Data Science
Univ.-Prof. Dr. Sascha Klee
Head of, Member of the Senate, Member of the Committee for Scientific Integrity and Ethics
Division of Biostatistics and Data Science
Prim. Clin. Ass. Prof. Dr. Peter Errhalt
Division of Pneumology (University Hospital Krems)
Prim. Univ.-Prof. Dr. Martin Pecherstorfer
Division of Internal Medicine 2 (University Hospital Krems)
OA Univ.-Prof. Mag. DDr. Klaus Podar
Head of
Division of Molecular Oncology and Hematology, Division of Internal Medicine 2 (University Hospital Krems)
OÄ PD Dr. Sonia Vallet
Division of Molecular Oncology and Hematology, Division of Internal Medicine 2 (University Hospital Krems)
